BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries | Zendy

Bowen Wang | Zendy; Mengxue Zhang | Zendy; Toshio Takayama | Zendy; Xudong Shi | Zendy; Drew Alan Roenneburg | Zendy; K. Craig Kent | Zendy; LianWang Guo | Zendy

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BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries

Author(s) -

Bowen Wang,

Mengxue Zhang,

Toshio Takayama,

Xudong Shi,

Drew Alan Roenneburg,

K. Craig Kent,

LianWang Guo

Publication year - 2015

Publication title -

ebiomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.596

H-Index - 63

ISSN - 2352-3964

DOI - 10.1016/j.ebiom.2015.09.045

Subject(s) - neointima , bromodomain , intimal hyperplasia , brd4 , cancer research , medicine , neointimal hyperplasia , bet inhibitor , hyperplasia , epigenetics , microbiology and biotechnology , pharmacology , endocrinology , chemistry , biology , restenosis , biochemistry , smooth muscle , stent , gene

Intimal hyperplasia is a common cause of many vasculopathies. There has been a recent surge of interest in the bromo and extra-terminal (BET) epigenetic "readers" including BRD4 since the serendipitous discovery of JQ1(+), an inhibitor specific to the seemingly undruggable BET bromodomains. The role of the BET family in the development of intimal hyperplasia is not known.

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