Intraepidermal sebaceous carcinoma with superficial dermal invasion of the nipple

Sebaceous carcinoma (SC) is a rare malignant neoplasm usually presenting as an ocular lesion or, less commonly, an extraocular cutaneous lesion mostly on the head and neck, whereas it seldom found on other sites. We present a case of a 56-year-old woman with SC on her left nipple. To our knowledge, this is the second reported SC arising in the nipple, but may be the first case of SC of the nipple displaying predominance in intraepidermal proliferation with superficial dermal invasion—a very seldom described growth pattern of extraocular SC in literature. An early invasive stage of the rare intraepidermal variant is suggested, with the location of the originating tumor cells being different from that of the usual intradermal cases. Free/ectopic sebaceous gland is one of the possible origins