Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer | Zendy

K. Maskos | Zendy; Alfred Lammens | Zendy; SengLai Tan | Zendy; Henry Hess | Zendy; Wolf Palinsky | Zendy; Pascal Schneider | Zendy; Xuliang Jiang | Zendy

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Data for the crystal structure of APRIL–BAFF–BAFF heterotrimer

Author(s) -

K. Maskos,

Alfred Lammens,

SengLai Tan,

Henry Hess,

Wolf Palinsky,

Pascal Schneider,

Xuliang Jiang

Publication year - 2015

Publication title -

data in brief

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 30

ISSN - 2352-3409

DOI - 10.1016/j.dib.2015.12.024

Subject(s) - b cell activating factor , orthorhombic crystal system , hek 293 cells , molecular replacement , chemistry , crystallography , ligand (biochemistry) , protein data bank (rcsb pdb) , crystal structure , biochemistry , b cell , biology , receptor , immunology , antibody

The TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) modulate B cell function by forming homotrimers and heterotrimers. To determine the structure of a heterotrimer of BAFF and APRIL, these ligands were expressed as a single chain protein in HEK 293 cells, purified by affinity and size exclusion chromatographies, and crystallized. Crystals belonging to the orthorhombic crystal system with a space group of C2221 diffracted to 2.43 Å. Initial structural solution was obtained by the molecular replacement method, and the structure was further refined to an R factor of 0.179 and free R factor of 0.234. The atomic coordinates and structure factors have been deposited into the Protein Data Bank (accession code 4ZCH).

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