Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening | Zendy

Elyse Dunn | Zendy; Gregory M. Cook | Zendy; Adam Heikal | Zendy

Open Access

Annotated compound data for modulators of detergent-solubilised or lipid-reconstituted respiratory type II NADH dehydrogenase activity obtained by compound library screening

Author(s) -

Elyse Dunn,

Gregory M. Cook,

Adam Heikal

Publication year - 2015

Publication title -

data in brief

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.122

H-Index - 30

ISSN - 2352-3409

DOI - 10.1016/j.dib.2015.12.019

Subject(s) - nadh dehydrogenase , respiratory chain , oxidoreductase , biochemistry , succinate dehydrogenase , membrane permeability , chemistry , enzyme , drug discovery , dehydrogenase , lactate dehydrogenase , membrane protein , combinatorial chemistry , membrane , protein subunit , gene

The energy-generating membrane protein NADH dehydrogenase (NDH-2), a proposed antibacterial drug target (see "Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs" Weinstein et al. 2005 [1]), was screened for modulators of activity in either detergent-solublised or lipid reconstituted (proteolipsome) form. Here we present an annotated list of compounds identified in a small-scale screen against NDH-2. The dataset contains information regarding the libraries screened, the identities of hit compounds and the physicochemical properties governing solubility and permeability. The implications of these data for future antibiotic discovery are discussed in our associated report, "Comparison of lipid and detergent enzyme environments for identifying inhibitors of membrane-bound energy-transducing proteins" [2].

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