Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer – A scoping review | Zendy

Sofia Hildingsson | Zendy; Maria GebreMedhin | Zendy; Sebastian Zschaeck | Zendy; Gabriel Adrian | Zendy

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Hypoxia in relationship to tumor volume using hypoxia PET-imaging in head & neck cancer – A scoping review

Author(s) -

Sofia Hildingsson,

Maria GebreMedhin,

Sebastian Zschaeck,

Gabriel Adrian

Publication year - 2022

Publication title -

clinical and translational radiation oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.336

H-Index - 15

ISSN - 2405-6308

DOI - 10.1016/j.ctro.2022.06.004

Subject(s) - hypoxia (environmental) , medicine , head and neck cancer , tumor hypoxia , pet imaging , nuclear medicine , cancer , positron emission tomography , radiology , radiation therapy , oxygen , chemistry , organic chemistry

Hypoxia and large tumor volumes are negative prognostic factors for patients with head and neck squamous cell carcinoma (HNSCC) treated with radiation therapy (RT). PET-scanning with specific hypoxia-tracers (hypoxia-PET) can be used to non-invasively assess hypoxic tumor volume. Primary tumor volume is readily available for patients undergoing RT. However, the relationship between hypoxic volume and primary tumor volume is yet an open question. The current study investigates the hypotheses that larger tumors contain both a larger hypoxic volume and a higher hypoxic fraction.

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