[18F]-HX4 PET/CT hypoxia in patients with squamous cell carcinoma of the head and neck treated with chemoradiotherapy: Prognostic results from two prospective trials | Zendy

Sebastian Sanduleanu | Zendy; Olga HammingVrieze | Zendy; Frederik Wesseling | Zendy; Aniek J.G. Even | Zendy; Frank Hoebers | Zendy; Ann Hoeben | Zendy; Wouter V. Vogel | Zendy; Margot Tesselaar | Zendy; Daniel Parvin | Zendy; Harry Bartelink | Zendy; Philippe Lambin | Zendy

Open Access

[18F]-HX4 PET/CT hypoxia in patients with squamous cell carcinoma of the head and neck treated with chemoradiotherapy: Prognostic results from two prospective trials

Author(s) -

Sebastian Sanduleanu,

Olga HammingVrieze,

Frederik Wesseling,

Aniek J.G. Even,

Frank Hoebers,

Ann Hoeben,

Wouter V. Vogel,

Margot Tesselaar,

Daniel Parvin,

Harry Bartelink,

Philippe Lambin

Publication year - 2020

Publication title -

clinical and translational radiation oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.336

H-Index - 15

ISSN - 2405-6308

DOI - 10.1016/j.ctro.2020.04.004

Subject(s) - medicine , proportional hazards model , tumor hypoxia , chemoradiotherapy , hypoxia (environmental) , univariate analysis , prospective cohort study , nuclear medicine , head and neck squamous cell carcinoma , survival analysis , radiation therapy , head and neck cancer , multivariate analysis , chemistry , organic chemistry , oxygen

The presence of hypoxia in head-and-neck squamous cell carcinoma is a negative prognostic factor. PET imaging with [18F] HX4 can be used to visualize hypoxia, but it is currently unknown how this correlates with prognosis. We investigated the prognostic value of [18F] HX4 PET imaging in patients treated with definitive radio(chemo)therapy (RTx).

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