Serum sickness-like reaction due to Infliximab reintroduction during pregnancy

Dear sir,The TNF-α inhibitor Infliximab (IFX) has the potential to induce immunogenicity. Episodic treatment with IFX increases the risk of infusion reactions as compared to scheduled treatment.1 We present a case of serum sickness-like symptoms in a pregnant woman with ulcerative colitis (UC) following IFX reintroduction.Debut of ulcerative pancolitis in a 26 year old woman was initially treated with systemic steroids. Remission was attained with IFX induction series with four infusions (5 mg/kg) followed by maintenance treatment with 5-aminosalicylic acid (5-ASA) 3200 mg daily.Flare in UC occurred around the time of conception 18 months …