Reply to Dr. Yamamoto's letter

Dear Sir,We would like to thank Dr. Yamamoto for his comments. We agree that ADA is a useful therapy for maintaining post-operative remission in patients intolerant and/or unresponsive to IFX and AZA. We also share his opinion that candidate patients for anti-TNFα treatment in the post-operative setting are mainly those who are at high-risk for post-operative recurrence (POR) of Crohn's disease (CD), especially if they have truly failed thiopurines pre-operatively and are endangered in the long-term by a disabling course of disease and/or intestinal failure.1Regarding the issues raised by Dr. Yamamoto …