Open AccessUrinary NMR metabolomic profiles discriminate inflammatory bowel disease from healthy
Author(s) -
Natasha S. Stephens,
Jesse Siffledeen,
Xiaorong Su,
Travis B. Murdoch,
Richard N. Fedorak,
Carolyn M. Slupsky
Publication year - 2012
Publication title -
journal of crohn s and colitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.277
H-Index - 80
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1016/j.crohns.2012.04.019
Subject(s) - inflammatory bowel disease , ulcerative colitis , medicine , metabolomics , urinary system , confounding , gastroenterology , disease , univariate analysis , metabolite , urine , gastrointestinal tract , multivariate analysis , crohn's disease , bioinformatics , biology
Inflammatory bowel disease, a chronic inflammation of the intestinal tract, presents in two variations, Ulcerative Colitis (UC) and Crohn's disease (CD). Given that treatment of CD differs from UC, a single test that provided strong diagnostic ability would offer great clinical value. Two previous studies have indicated that CD can be distinguished from UC, and that both can be distinguished from non-IBD-type gastrointestinal disease, based on urinary and faecal metabolite profiling.
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