Open AccessLow mannose-binding lectin (MBL) is associated with paediatric inflammatory bowel diseases and ileal involvement in patients with Crohn disease
Author(s) -
Márta Kovács,
Mária Papp,
Péter L. Lakatos,
Silvia Jacobsen,
Éva Nemes,
Marianne Polgár,
Enikő Sólyom,
Piroska Bódi,
Ágnes Horváth,
Kriszta Molnár,
Dolóresz Szabó,
Áron Cseh,
Katalin Eszter Müller,
Antal Dezsőfi,
András Arató,
Gábor Veres
Publication year - 2012
Publication title -
journal of crohn s and colitis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.277
H-Index - 80
eISSN - 1876-4479
pISSN - 1873-9946
DOI - 10.1016/j.crohns.2012.03.008
Subject(s) - mannan binding lectin , immunology , nod2 , medicine , inflammatory bowel disease , ulcerative colitis , serology , panca , autoantibody , pathogenesis , crohn's disease , gastroenterology , disease , antibody , lectin , anti neutrophil cytoplasmic antibody , vasculitis
Mannose-binding lectin (MBL) is a pattern-recognition molecule of the innate immune system and may be involved in the pathogenesis of inflammatory bowel disease (IBD). Our aim was to assess the prevalence of MBL deficiency in a cohort of patients with paediatric-onset IBD and study whether it is associated with the clinical manifestations, serum antibody formation, or genetic factors.
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