Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity | Zendy

Thomas Schaffer | Zendy; Beatrice Flogerzi | Zendy; Alain Schoepfer | Zendy; Frank Seibold | Zendy; Stefan Müller | Zendy

Open Access

Increased titers of anti-Saccharomyces cerevisiae antibodies in Crohn's disease patients with reduced H-ficolin levels but normal MASP-2 activity

Author(s) -

Thomas Schaffer,

Beatrice Flogerzi,

Alain Schoepfer,

Frank Seibold,

Stefan Müller

Publication year - 2012

Publication title -

journal of crohn s and colitis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.277

H-Index - 80

eISSN - 1876-4479

pISSN - 1873-9946

DOI - 10.1016/j.crohns.2012.02.013

Subject(s) - ficolin , autoantibody , lectin pathway , mannan binding lectin , immunology , complement system , antibody , biology , titer , lectin , classical complement pathway

Mannan-binding lectin (MBL) and ficolins are microbial pattern recognition molecules that activate the lectin pathway of complement. We previously reported the association of MBL deficiency with anti-Saccharomyces cerevisiae antibodies (ASCA) in patients with Crohn's disease (CD). However, ASCA are also frequently found in MBL-proficient CD patients. Here we addressed expression/function of ficolins and MBL-associated serine protease-2 (MASP-2) regarding potential association with ASCA.

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