Open AccessIdentification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants
Author(s) -
Imran Khan,
Akiko Koide,
Mariyam Zuberi,
Gayatri Ketavarapu,
Eric Denbaum,
Kai Wen Teng,
J. Matthew Rhett,
Russell Spencer-Smith,
G. Aaron Hobbs,
E. Ramsay Camp,
Shohei Koide,
John P. O’Bryan
Publication year - 2022
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2022.110322
Subject(s) - mutant , guanine nucleotide exchange factor , gtpase , biology , kras , mutation , microbiology and biotechnology , guanosine , synthetic lethality , intracellular , gene isoform , phenotypic screening , cancer research , phenotype , genetics , gene
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom