Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD | Zendy

Yanwei Wu | Zendy; Wei Shao | Zendy; Tiffany W. Todd | Zendy; Jimei Tong | Zendy; Mei Yue | Zendy; Shunsuke Koga | Zendy; Monica CastanedesCasey | Zendy; Ariston L Librero | Zendy; Chris W. Lee | Zendy; Ian R. Mackenzie | Zendy; Dennis W. Dickson | Zendy; YongJie Zhang | Zendy; Leonard Petrucelli | Zendy; Mercedes Prudencio | Zendy

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Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD

Author(s) -

Yanwei Wu,

Wei Shao,

Tiffany W. Todd,

Jimei Tong,

Mei Yue,

Shunsuke Koga,

Monica CastanedesCasey,

Ariston L Librero,

Chris W. Lee,

Ian R. Mackenzie,

Dennis W. Dickson,

YongJie Zhang,

Leonard Petrucelli,

Mercedes Prudencio

Publication year - 2021

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2021.109581

Subject(s) - microglia , myelin , frontotemporal dementia , white matter , cathepsin d , neuroinflammation , biology , frontotemporal lobar degeneration , knockout mouse , pathology , microbiology and biotechnology , lysosome , neuroscience , immunology , medicine , dementia , disease , inflammation , gene , central nervous system , genetics , enzyme , biochemistry , radiology , magnetic resonance imaging

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