Open AccessPatient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
Author(s) -
Michelle L. Wegscheid,
Corina Anastasaki,
Kelly Hartigan,
Olivia Cobb,
Jason B. Papke,
Jennifer N. Traber,
Stephanie M. Morris,
David H. Gutmann
Publication year - 2021
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2021.109315
Subject(s) - biology , neurogenesis , forebrain , rhoa , neural stem cell , epigenetics , induced pluripotent stem cell , haploinsufficiency , regulator , neurofibromatosis , genetics , gene , stem cell , neuroscience , signal transduction , phenotype , embryonic stem cell , central nervous system
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