NLRP6 in host defense and intestinal inflammation | Zendy

K. Venuprasad | Zendy; Arianne L. Theiss | Zendy

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NLRP6 in host defense and intestinal inflammation

Author(s) -

K. Venuprasad,

Arianne L. Theiss

Publication year - 2021

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2021.109043

Subject(s) - inflammasome , caspase 1 , microbiology and biotechnology , nlrc4 , biology , pyrin domain , inflammation , function (biology) , pathogen , receptor , immunology , genetics

SUMMARY NLRP6 is a member of the NLR (nucleotide-oligomerization domain-like receptor) family of proteins that recognize pathogen-derived factors and damage-associated molecular patterns in the cytosol. The function of NLRP6 has been attributed to the maintenance of epithelial integrity and host defense against microbial infections. Under some physiological conditions, NLRP6 forms a complex with ASC and caspase-1 or caspase-11 to form an inflammasome complex cleaving pro-interleukin-1β(IL-1β) and IL-18 into their biologically active forms. Here, we summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.

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