Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2 | Zendy

Romain Gasser | Zendy; Marc Cloutier | Zendy; Jérémie Prévost | Zendy; Corby Fink | Zendy; Éric Ducas | Zendy; Shilei Ding | Zendy; Nathalie Dussault | Zendy; Patricia Landry | Zendy; Tony Tremblay | Zendy; Audrey LaforceLavoie | Zendy; Antoine Lewin | Zendy; Guillaume Beaudoin-Bussières | Zendy; Annemarie Laumaea | Zendy; Halima Medjahed | Zendy; Catherine Larochelle | Zendy; Jonathan Richard | Zendy; Gregory A. Dekaban | Zendy; Jimmy D. Dikeakos | Zendy; Renée Bazin | Zendy; Andrés Finzi | Zendy

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Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2

Author(s) -

Romain Gasser,

Marc Cloutier,

Jérémie Prévost,

Corby Fink,

Éric Ducas,

Shilei Ding,

Nathalie Dussault,

Patricia Landry,

Tony Tremblay,

Audrey LaforceLavoie,

Antoine Lewin,

Guillaume Beaudoin-Bussières,

Annemarie Laumaea,

Halima Medjahed,

Catherine Larochelle,

Jonathan Richard,

Gregory A. Dekaban,

Jimmy D. Dikeakos,

Renée Bazin,

Andrés Finzi

Publication year - 2021

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2021.108790

Subject(s) - antibody , neutralization , convalescent plasma , isotype , immunology , immunoglobulin g , covid-19 , neutralizing antibody , virology , virus , immunoglobulin m , medicine , monoclonal antibody , disease , infectious disease (medical specialty)

Characterization of the humoral response to SARS-CoV-2, the etiological agent of COVID-19, is essential to help control the infection. The neutralization activity of plasma from COVID-19 patients decreases rapidly during the first weeks after recovery. However, the specific role of each immunoglobulin isotype in the overall neutralizing capacity is still not well understood. In this study, we select plasma from a cohort of COVID-19 convalescent patients and selectively deplete immunoglobulin A, M or G before testing the remaining neutralizing capacity of the depleted plasma. We find that depletion of immunoglobulin M is associated with the most substantial loss of virus neutralization, followed by immunoglobulin G. This observation may help design efficient antibody-based COVID-19 therapies and may also explain the increased susceptibility to SARS-CoV-2 of autoimmune patients receiving therapies that impair the production of IgM.

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