Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients | Zendy

Anthony T. Tan | Zendy; Martin Linster | Zendy; Chee Wah Tan | Zendy; Nina Le Bert | Zendy; Wan Ni Chia | Zendy; Kamini Kunasegaran | Zendy; Yan Zhuang | Zendy; C Tham | Zendy; Adeline Chia | Zendy; Gavin J. D. Smith | Zendy; Barnaby Edward Young | Zendy; Shirin Kalimuddin | Zendy; Jenny G. Low | Zendy; David Chien Lye | Zendy; LinFa Wang | Zendy; Antonio Bertoletti | Zendy

Open Access

Early induction of functional SARS-CoV-2-specific T cells associates with rapid viral clearance and mild disease in COVID-19 patients

Author(s) -

Anthony T. Tan,

Martin Linster,

Chee Wah Tan,

Nina Le Bert,

Wan Ni Chia,

Kamini Kunasegaran,

Yan Zhuang,

C Tham,

Adeline Chia,

Gavin J. D. Smith,

Barnaby Edward Young,

Shirin Kalimuddin,

Jenny G. Low,

David Chien Lye,

LinFa Wang,

Antonio Bertoletti

Publication year - 2021

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2021.108728

Subject(s) - convalescence , immune system , immunology , virology , antibody , virus , disease , coronaviridae , biology , humoral immunity , nucleoprotein , viral load , interferon , medicine , covid-19 , infectious disease (medical specialty)

Virus-specific humoral and cellular immunity act synergistically to protect the host from viral infection. We interrogate the dynamic changes of virological and immunological parameters in 12 patients with symptomatic acute SARS-CoV-2 infection from disease onset to convalescence or death. We quantify SARS-CoV-2 viral RNA in the respiratory tract in parallel with antibodies and circulating T cells specific for various structural (NP, M, ORF3a and spike) and non-structural proteins (ORF7/8, NSP7 and NSP13). While rapid induction and quantity of humoral responses associates with an increase in disease severity, early induction of IFN-γ secreting SARS-CoV-2 specific T cells is present in patients with mild disease and accelerated viral clearance. These findings provide support for the prognostic value of early functional SARS-CoV-2 specific T cells with important implications in vaccine design and immune monitoring.

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