Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains | Zendy

Christian Haenig | Zendy; Nir Atias | Zendy; Alexander K. Taylor | Zendy; Ar Mazza | Zendy; Martin H. Schaefer | Zendy; Jenny Russ | Zendy; SeanPatrick Riechers | Zendy; Shushant Jain | Zendy; Maura Coughlin | Zendy; Jean−Fred Fontaine | Zendy; Brian D. Freibaum | Zendy; Lydia Brusendorf | Zendy; Martina Zenkner | Zendy; Pablo Porras | Zendy; Martin Stroedicke | Zendy; Sigrid Schnoegl | Zendy; Kristin Arnsburg | Zendy; Annett Boeddrich | Zendy; Lucia Pigazzini | Zendy; Peter Heutink | Zendy; J. Paul Taylor | Zendy; Janine Kirstein | Zendy; Miguel A. AndradeNavarro | Zendy; Roded Sharan | Zendy; Erich E. Wanker | Zendy

Open Access

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Author(s) -

Christian Haenig,

Nir Atias,

Alexander K. Taylor,

Ar Mazza,

Martin H. Schaefer,

Jenny Russ,

SeanPatrick Riechers,

Shushant Jain,

Maura Coughlin,

Jean−Fred Fontaine,

Brian D. Freibaum,

Lydia Brusendorf,

Martina Zenkner,

Pablo Porras,

Martin Stroedicke,

Sigrid Schnoegl,

Kristin Arnsburg,

Annett Boeddrich,

Lucia Pigazzini,

Peter Heutink,

J. Paul Taylor,

Janine Kirstein,

Miguel A. AndradeNavarro,

Roded Sharan,

Erich E. Wanker

Publication year - 2020

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2020.108050

Subject(s) - interactome , interconnectivity , computational biology , biology , protein–protein interaction , disease , protein aggregation , function (biology) , identification (biology) , amyloid (mycology) , neuroscience , bioinformatics , microbiology and biotechnology , genetics , gene , medicine , computer science , pathology , artificial intelligence , botany

Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions and is generated by systematic yeast two-hybrid interaction screening of ∼500 ND-related proteins and integration of literature interactions. This network reveals interconnectivity across diseases and links many known ND-causing proteins, such as α-synuclein, TDP-43, and ATXN1, to a host of proteins previously unrelated to NDs. It facilitates the identification of interacting proteins that significantly influence mutant TDP-43 and HTT toxicity in transgenic flies, as well as of ARF-GEP that controls misfolding and aggregation of multiple ND-causing proteins in experimental model systems. Furthermore, it enables the prediction of ND-specific subnetworks and the identification of proteins, such as ATXN1 and MKL1, that are abnormally aggregated in postmortem brains of Alzheimer's disease patients, suggesting widespread protein aggregation in NDs.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research