LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma | Zendy

Tugba Keskin | Zendy; Arnaud Bakaric | Zendy; Patricia Waszyk | Zendy; Gaylor Boulay | Zendy; Matteo Torsello | Zendy; Sandrine Cornaz-Buros | Zendy; Nadja Chevalier | Zendy; Thibaud Geiser | Zendy; Patricia Martin | Zendy; Angela Volorio | Zendy; Sowmya Iyer | Zendy; Anupriya S. Kulkarni | Zendy; Igor Letovanec | Zendy; Stéphane Cherix | Zendy; Gregory M. Coté | Zendy; Edwin Choy | Zendy; Antonia Digklia | Zendy; Michael Montemurro | Zendy; Ivan Chebib | Zendy; Petur Nielsen | Zendy; Ángel M. Carcaboso | Zendy; Jaume Mora | Zendy; Raffaele Renella | Zendy; Mario L. Suvà | Zendy; Carlo Fusco | Zendy; Paolo Provero | Zendy; Miguel N. Rivera | Zendy; Nicolò Riggi | Zendy; Ivan Stamenkovic | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma

Author(s) -

Tugba Keskin,

Arnaud Bakaric,

Patricia Waszyk,

Gaylor Boulay,

Matteo Torsello,

Sandrine Cornaz-Buros,

Nadja Chevalier,

Thibaud Geiser,

Patricia Martin,

Angela Volorio,

Sowmya Iyer,

Anupriya S. Kulkarni,

Igor Letovanec,

Stéphane Cherix,

Gregory M. Coté,

Edwin Choy,

Antonia Digklia,

Michael Montemurro,

Ivan Chebib,

Petur Nielsen,

Ángel M. Carcaboso,

Jaume Mora,

Raffaele Renella,

Mario L. Suvà,

Carlo Fusco,

Paolo Provero,

Miguel N. Rivera,

Nicolò Riggi,

Ivan Stamenkovic

Publication year - 2020

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.12.053

Subject(s) - pathogenesis , cancer research , biology , fli1 , rna binding protein , sarcoma , fusion protein , rna , computational biology , bioinformatics , medicine , transcription factor , gene , genetics , immunology , pathology , recombinant dna

Ewing sarcoma (EwS) is associated with poor prognosis despite current multimodal therapy. Targeting of EWS-FLI1, the fusion protein responsible for its pathogenesis, and its principal downstream targets has not yet produced satisfactory therapeutic options, fueling the search for alternative approaches. Here, we show that the oncofetal RNA-binding protein LIN28B regulates the stability of EWS-FLI1 mRNA in ~10% of EwSs. LIN28B depletion in these tumors leads to a decrease in the expression of EWS-FLI1 and its direct transcriptional network, abrogating EwS cell self-renewal and tumorigenicity. Moreover, pharmacological inhibition of LIN28B mimics the effect of LIN28B depletion, suggesting that LIN28B sustains the emergence of a subset of EwS in which it also serves as an effective therapeutic target.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research