miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer | Zendy

Deepak Parashar | Zendy; Anjali Geethadevi | Zendy; Miriam R. R. Aure | Zendy; Jyotsna Mishra | Zendy; Jasmine George | Zendy; Changliang Chen | Zendy; Manoj K. Mishra | Zendy; Andliena Tahiri | Zendy; Wei Zhao | Zendy; Bindu Nair | Zendy; Yiling Lu | Zendy; Lingegowda S. Mangala | Zendy; Cristian RodriguezAguayo | Zendy; Gabriel López-Berestein | Zendy; Amadou K.S. Camara | Zendy; Mingyu Liang | Zendy; Janet S. Rader | Zendy; Ramani Ramchandran | Zendy; Ming You | Zendy; Anil K. Sood | Zendy; Vessela N. Kristensen | Zendy; Gordon B. Mills | Zendy; Sunila Pradeep | Zendy; Pradeep ChaluvallyRaghavan | Zendy

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miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer

Author(s) -

Deepak Parashar,

Anjali Geethadevi,

Miriam R. R. Aure,

Jyotsna Mishra,

Jasmine George,

Changliang Chen,

Manoj K. Mishra,

Andliena Tahiri,

Wei Zhao,

Bindu Nair,

Yiling Lu,

Lingegowda S. Mangala,

Cristian RodriguezAguayo,

Gabriel López-Berestein,

Amadou K.S. Camara,

Mingyu Liang,

Janet S. Rader,

Ramani Ramchandran,

Ming You,

Anil K. Sood,

Vessela N. Kristensen,

Gordon B. Mills,

Sunila Pradeep,

Pradeep ChaluvallyRaghavan

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.11.085

Subject(s) - triple negative breast cancer , oncostatin m , breast cancer , cancer research , triple negative , cancer , signal transduction , chemistry , biology , medicine , microbiology and biotechnology , interleukin 6 , inflammation

Genomic amplification of 3q26.2 locus leads to the increased expression of microRNA 551b-3p (miR551b-3p) in triple-negative breast cancer (TNBC). Our results demonstrate that miR551b-3p translocates to the nucleus with the aid of importin-8 (IPO8) and activates STAT3 transcription. As a consequence, miR551b upregulates the expression of oncostatin M receptor (OSMR) and interleukin-31 receptor-α (IL-31RA) as well as their ligands OSM and IL-31 through STAT3 transcription. We defined this set of genes induced by miR551b-3p as the "oncostatin signaling module," which provides oncogenic addictions in cancer cells. Notably, OSM is highly expressed in TNBC, and the elevated expression of OSM associates with poor outcome in estrogen-receptor-negative breast cancer patients. Conversely, targeting miR551b with anti-miR551b-3p reduced the expression of the OSM signaling module and reduced tumor growth, as well as migration and invasion of breast cancer cells.

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