Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming | Zendy

Arie J. Hoogendijk | Zendy; Farzin Pourfarzad | Zendy; Cathelijn E.M. Aarts | Zendy; Anton T. J. Tool | Zendy; Ida H. Hiemstra | Zendy; Luigi Grassi | Zendy; Mattia Frontini | Zendy; Alexander B. Meijer | Zendy; Maartje van den Biggelaar | Zendy; Taco W. Kuijpers | Zendy

Open Access

Dynamic Transcriptome-Proteome Correlation Networks Reveal Human Myeloid Differentiation and Neutrophil-Specific Programming

Author(s) -

Arie J. Hoogendijk,

Farzin Pourfarzad,

Cathelijn E.M. Aarts,

Anton T. J. Tool,

Ida H. Hiemstra,

Luigi Grassi,

Mattia Frontini,

Alexander B. Meijer,

Maartje van den Biggelaar,

Taco W. Kuijpers

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.10.082

Subject(s) - transcriptome , proteome , biology , progenitor cell , proteomics , innate immune system , myeloid cells , myeloid , bone marrow , microbiology and biotechnology , immunology , stem cell , immune system , bioinformatics , gene expression , genetics , gene

Human neutrophilic granulocytes form the largest pool of innate immune cells for host defense against bacterial and fungal pathogens. The dynamic changes that accompany the metamorphosis from a proliferating myeloid progenitor cell in the bone marrow into a mature non-dividing polymorphonuclear blood cell have remained poorly defined. Using mass spectrometry-based quantitative proteomics combined with transcriptomic data, we report on the dynamic changes of five developmental stages in the bone marrow and blood. Integration of transcriptomes and proteome unveils highly dynamic and differential interactions between RNA and protein kinetics during human neutrophil development, which can be linked to functional maturation of typical end-stage blood neutrophil killing activities.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research