Open AccessAvian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin
Author(s) -
Ying Xu,
Ruchao Peng,
Wei Zhang,
Jianxun Qi,
Hao Song,
Sheng Liu,
Haiyuan Wang,
Min Wang,
Haixia Xiao,
Lifeng Fu,
Zheng Fan,
Yuhai Bi,
Jinghua Yan,
Yi Shi,
George F. Gao
Publication year - 2019
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2019.10.047
Subject(s) - hemagglutinin (influenza) , virology , influenza a virus subtype h5n1 , h5n1 genetic structure , biology , virus , adaptation (eye) , influenza a virus , avian influenza virus , receptor , covid-19 , genetics , medicine , disease , pathology , infectious disease (medical specialty) , neuroscience
Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether H7N9 AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA), which is a critical determinant of interspecies transmission, shows that the current H7N9 AIVs are still dual-receptor tropic, indicating limited human-to-human transmission potency. Mutagenesis and structural studies reveal that a G186V substitution is sufficient for H7N9 AIVs to acquire human receptor-binding capacity, and a Q226L substitution would favor binding to both avian and human receptors only when paired with A138/V186/P221 hydrophobic residues. These data suggest a different evolutionary route of H7N9 viruses compared to other AIV-subtype HAs.
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