The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development | Zendy

MarieKristin Raulf | Zendy; Timo Johannssen | Zendy; Svea Matthiesen | Zendy; Konstantin Neumann | Zendy; Severin Hachenberg | Zendy; Sabine Mayer-Lambertz | Zendy; Fridolin Steinbeis | Zendy; Jan Hegermann | Zendy; Peter H. Seeberger | Zendy; Wolfgang Baumgärtner | Zendy; Christina Strübe | Zendy; Jürgen Ruland | Zendy; Bernd Lepenies | Zendy

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The C-type Lectin Receptor CLEC12A Recognizes Plasmodial Hemozoin and Contributes to Cerebral Malaria Development

Author(s) -

MarieKristin Raulf,

Timo Johannssen,

Svea Matthiesen,

Konstantin Neumann,

Severin Hachenberg,

Sabine Mayer-Lambertz,

Fridolin Steinbeis,

Jan Hegermann,

Peter H. Seeberger,

Wolfgang Baumgärtner,

Christina Strübe,

Jürgen Ruland,

Bernd Lepenies

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.06.015

Subject(s) - hemozoin , plasmodium berghei , cerebral malaria , c type lectin , innate immune system , immunology , malaria , biology , receptor , immunity , lectin , plasmodium falciparum , immune system , biochemistry

Malaria represents a major cause of death from infectious disease. Hemozoin is a Plasmodium-derived product that contributes to progression of cerebral malaria. However, there is a gap of knowledge regarding how hemozoin is recognized by innate immunity. Myeloid C-type lectin receptors (CLRs) encompass a family of carbohydrate-binding receptors that act as pattern recognition receptors in innate immunity. In the present study, we identify the CLR CLEC12A as a receptor for hemozoin. Dendritic cell-T cell co-culture assays indicate that the CLEC12A/hemozoin interaction enhances CD8 + T cell cross-priming. Using the Plasmodium berghei Antwerpen-Kasapa (ANKA) mouse model of experimental cerebral malaria (ECM), we find that CLEC12A deficiency protects mice from ECM, illustrated by reduced ECM incidence and ameliorated clinical symptoms. In conclusion, we identify CLEC12A as an innate sensor of plasmodial hemozoin.

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