The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer | Zendy

Leticia De MattosArruda | Zendy; StephenJohn Sammut | Zendy; Edith Ross | Zendy; Rachael Bashford-Rogers | Zendy; Erez Greenstein | Zendy; Havell Markus | Zendy; Sandro Morganella | Zendy; Yvonne H. F. Teng | Zendy; Yosef E. Maruvka | Zendy; Bernard Pereira | Zendy; Oscar M. Rueda | Zendy; SuetFeung Chin | Zendy; Tania ContenteCuomo | Zendy; Regina Mayor | Zendy; Alexandra Arias | Zendy; H. Raza Ali | Zendy; Wei Cope | Zendy; Daniel Guimarães Tiezzi | Zendy; Aliakbar Dariush | Zendy; Tauanne Dias Amarante | Zendy; Dan Reshef | Zendy; Nikaoly Ciriaco | Zendy; Elena MartínezSáez | Zendy; Vicente Peg | Zendy; Santiago Ramón y Cajal | Zendy; Javier Cortés | Zendy; George S. Vassiliou | Zendy; Gad Getz | Zendy; SereikZainal | Zendy; Muhammed Murtaza | Zendy; Nir Friedman | Zendy; Florian Markowetz | Zendy; Joan Seoane | Zendy; Carlos Caldas | Zendy

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The Genomic and Immune Landscapes of Lethal Metastatic Breast Cancer

Author(s) -

Leticia De MattosArruda,

StephenJohn Sammut,

Edith Ross,

Rachael Bashford-Rogers,

Erez Greenstein,

Havell Markus,

Sandro Morganella,

Yvonne H. F. Teng,

Yosef E. Maruvka,

Bernard Pereira,

Oscar M. Rueda,

SuetFeung Chin,

Tania ContenteCuomo,

Regina Mayor,

Alexandra Arias,

H. Raza Ali,

Wei Cope,

Daniel Guimarães Tiezzi,

Aliakbar Dariush,

Tauanne Dias Amarante,

Dan Reshef,

Nikaoly Ciriaco,

Elena MartínezSáez,

Vicente Peg,

Santiago Ramón y Cajal,

Javier Cortés,

George S. Vassiliou,

Gad Getz,

SereikZainal,

Muhammed Murtaza,

Nir Friedman,

Florian Markowetz,

Joan Seoane,

Carlos Caldas

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.04.098

Subject(s) - immunoediting , loss of heterozygosity , immune system , biology , breast cancer , metastatic breast cancer , cancer research , cancer , immunology , immunotherapy , genetics , allele , gene

The detailed molecular characterization of lethal cancers is a prerequisite to understanding resistance to therapy and escape from cancer immunoediting. We performed extensive multi-platform profiling of multi-regional metastases in autopsies from 10 patients with therapy-resistant breast cancer. The integrated genomic and immune landscapes show that metastases propagate and evolve as communities of clones, reveal their predicted neo-antigen landscapes, and show that they can accumulate HLA loss of heterozygosity (LOH). The data further identify variable tumor microenvironments and reveal, through analyses of T cell receptor repertoires, that adaptive immune responses appear to co-evolve with the metastatic genomes. These findings reveal in fine detail the landscapes of lethal metastatic breast cancer.

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