Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation | Zendy

Dijue Sun | Zendy; Urszula StopkaFarooqui | Zendy; Sayka Barry | Zendy; Ezra Aksoy | Zendy; Gregory Parsonage | Zendy; Anna Vossenkämper | Zendy; Melania Capasso | Zendy; Xinyu Wan | Zendy; Sherine Norris | Zendy; Jennifer L. Marshall | Zendy; Andrew Clear | Zendy; John G. Gribben | Zendy; Thomas T. MacDonald | Zendy; Christopher D. Buckley | Zendy; Márta Korbonits | Zendy; Oliver Haworth | Zendy

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Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation

Author(s) -

Dijue Sun,

Urszula StopkaFarooqui,

Sayka Barry,

Ezra Aksoy,

Gregory Parsonage,

Anna Vossenkämper,

Melania Capasso,

Xinyu Wan,

Sherine Norris,

Jennifer L. Marshall,

Andrew Clear,

John G. Gribben,

Thomas T. MacDonald,

Christopher D. Buckley,

Márta Korbonits,

Oliver Haworth

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.04.014

Subject(s) - bcl6 , germinal center , ubiquitin ligase , ubiquitin , somatic hypermutation , b cell , chemistry , deubiquitinating enzyme , biology , microbiology and biotechnology , cancer research , heat shock protein , protein degradation , antibody , biochemistry , immunology , gene

B cell lymphoma-6 (BCL6) is highly expressed in germinal center B cells, but how its expression is maintained is still not completely clear. Aryl hydrocarbon receptor interacting protein (AIP) is a co-chaperone of heat shock protein 90. Deletion of Aip in B cells decreased BCL6 expression, reducing germinal center B cells and diminishing adaptive immune responses. AIP was required for optimal AKT signaling in response to B cell receptor stimulation, and AIP protected BCL6 from ubiquitin-mediated proteasomal degradation by the E3-ubiquitin ligase FBXO11 by binding to the deubiquitinase UCHL1, thus helping to maintain the expression of BCL6. AIP was highly expressed in primary diffuse large B cell lymphomas compared to healthy tissue and other tumors. Our findings describe AIP as a positive regulator of BCL6 expression with implications for the pathobiology of diffuse large B cell lymphoma.

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