Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor | Zendy

Stephanie Redmond | Zendy; María Figueres-Oñate | Zendy; Kirsten Obernier | Zendy; Marcos Assis Nascimento | Zendy; Jose I. Parraguez | Zendy; Laura LópezMascaraque | Zendy; Luis C. Fuentealba | Zendy; Arturo Álvarez-Buylla | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor

Author(s) -

Stephanie Redmond,

María Figueres-Oñate,

Kirsten Obernier,

Marcos Assis Nascimento,

Jose I. Parraguez,

Laura LópezMascaraque,

Luis C. Fuentealba,

Arturo Álvarez-Buylla

Publication year - 2019

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2019.01.088

Subject(s) - embryonic stem cell , biology , ependymal cell , microbiology and biotechnology , neural stem cell , stem cell , progenitor cell , lineage (genetic) , germinal epithelium , cilium , embryogenesis , anatomy , embryo , neuroscience , genetics , central nervous system , gene , endocrinology , spermatogenesis

The adult mouse brain contains an extensive neurogenic niche in the lateral walls of the lateral ventricles. This epithelium, which has a unique pinwheel organization, contains multiciliated ependymal (E1) cells and neural stem cells (B1). This postnatal germinal epithelium develops from the embryonic ventricular zone, but the lineage relationship between E1 and B1 cells remains unknown. Distinct subpopulations of radial glia (RG) cells in late embryonic and early postnatal development either expand their apical domain >11-fold to form E1 cells or retain small apical domains that coalesce into the centers of pinwheels to form B1 cells. Using independent methods of lineage tracing, we show that individual RG cells can give rise to clones containing E1 and B1 cells. This study reveals key developmental steps in the formation of the postnatal germinal niche and the shared cellular origin of E1 and B1 cells.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research