Open AccessMafb and c-Maf Have Prenatal Compensatory and Postnatal Antagonistic Roles in Cortical Interneuron Fate and Function
Author(s) -
Emily Ling-Lin Pai,
Daniel Vogt,
Alexandra Clemente-Perez,
Gabriel L. McKinsey,
Frances S. Cho,
Jia Sheng Hu,
Matt Wimer,
Anirban Paul,
Siavash Fazel Darbandi,
Ramón Pla,
Tomasz J. Nowakowski,
Lisa V. Goodrich,
Jeanne T. Paz,
John L.R. Rubenstein
Publication year - 2019
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2019.01.031
Subject(s) - ganglionic eminence , biology , interneuron , parvalbumin , synaptogenesis , transcription factor , neuroscience , progenitor cell , progenitor , microbiology and biotechnology , stem cell , genetics , inhibitory postsynaptic potential , gene
Mafb and c-Maf transcription factor (TF) expression is enriched in medial ganglionic eminence (MGE) lineages, beginning in late-secondary progenitors and continuing into mature parvalbumin (PV + ) and somatostatin (SST + ) interneurons. However, the functions of Maf TFs in MGE development remain to be elucidated. Herein, Mafb and c-Maf were conditionally deleted, alone and together, in the MGE and its lineages. Analyses of Maf mutant mice revealed redundant functions of Mafb and c-Maf in secondary MGE progenitors, where they repress the generation of SST + cortical and hippocampal interneurons. By contrast, Mafb and c-Maf have distinct roles in postnatal cortical interneuron (CIN) morphological maturation, synaptogenesis, and cortical circuit integration. Thus, Mafb and c-Maf have redundant and opposing functions at different steps in CIN development.
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