Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence | Zendy

Iain D. Miller | Zendy; Mingwei Min | Zendy; Chen Yang | Zendy; Chengzhe Tian | Zendy; Sara E. Gookin | Zendy; Dylan Carter | Zendy; Sabrina L. Spencer | Zendy

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Ki67 is a Graded Rather than a Binary Marker of Proliferation versus Quiescence

Author(s) -

Iain D. Miller,

Mingwei Min,

Chen Yang,

Chengzhe Tian,

Sara E. Gookin,

Dylan Carter,

Sabrina L. Spencer

Publication year - 2018

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2018.06.110

Subject(s) - cell growth , proliferation marker , endogeny , microbiology and biotechnology , cell cycle , biology , function (biology) , cell cycle progression , cell , andrology , chemistry , endocrinology , medicine , genetics

Ki67 staining is widely used as a proliferation indicator in the clinic, despite poor understanding of this protein's function or dynamics. Here, we track Ki67 levels under endogenous control in single cells over time and find that Ki67 accumulation occurs only during S, G2, and M phases. Ki67 is degraded continuously in G1 and G0 phases, regardless of the cause of entry into G0/quiescence. Consequently, the level of Ki67 during G0 and G1 in individual cells is highly heterogeneous and depends on how long an individual cell has spent in G0. Thus, Ki67 is a graded rather than a binary marker both for cell-cycle progression and time since entry into quiescence.

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