The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development | Zendy

Inês CunhaFerreira | Zendy; Anaël Chazeau | Zendy; Robin R. Buijs | Zendy; Riccardo Stucchi | Zendy; Lena Will | Zendy; Xingxiu Pan | Zendy; Youri Adolfs | Zendy; Christiaan van der Meer | Zendy; Joanna C. Wolthuis | Zendy; Olga I. Kahn | Zendy; Philipp Schätzle | Zendy; Maarten Altelaar | Zendy; R. Jeroen Pasterkamp | Zendy; Lukas C. Kapitein | Zendy; Casper C. Hoogenraad | Zendy

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The HAUS Complex Is a Key Regulator of Non-centrosomal Microtubule Organization during Neuronal Development

Author(s) -

Inês CunhaFerreira,

Anaël Chazeau,

Robin R. Buijs,

Riccardo Stucchi,

Lena Will,

Xingxiu Pan,

Youri Adolfs,

Christiaan van der Meer,

Joanna C. Wolthuis,

Olga I. Kahn,

Philipp Schätzle,

Maarten Altelaar,

R. Jeroen Pasterkamp,

Lukas C. Kapitein,

Casper C. Hoogenraad

Publication year - 2018

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2018.06.093

Subject(s) - centrosome , microtubule , microbiology and biotechnology , microtubule nucleation , biology , cell polarity , cytoskeleton , protein subunit , microtubule organizing center , mitosis , regulator , tubulin , cell , cell cycle , genetics , gene

Neuron morphology and function are highly dependent on proper organization of the cytoskeleton. In neurons, the centrosome is inactivated early in development, and acentrosomal microtubules are generated by mechanisms that are poorly understood. Here, we show that neuronal migration, development, and polarization depend on the multi-subunit protein HAUS/augmin complex, previously described to be required for mitotic spindle assembly in dividing cells. The HAUS complex is essential for neuronal microtubule organization by ensuring uniform microtubule polarity in axons and regulation of microtubule density in dendrites. Using live-cell imaging and high-resolution microscopy, we found that distinct HAUS clusters are distributed throughout neurons and colocalize with γ-TuRC, suggesting local microtubule nucleation events. We propose that the HAUS complex locally regulates microtubule nucleation events to control proper neuronal development.

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