Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism | Zendy

Matthew D. Lynes | Zendy; Farnaz Shamsi | Zendy; Elahu G. Sustarsic | Zendy; Luiz O. Leiria | Zendy; ChihHao Wang | Zendy; ShengChiang Su | Zendy; Tian Lian Huang | Zendy; Fei Gao | Zendy; Niven R. Narain | Zendy; Emily Y. Chen | Zendy; Aaron M. Cypess | Zendy; Tim J. Schulz | Zendy; Zachary GerhartHines | Zendy; Michael A. Kiebish | Zendy; YuHua Tseng | Zendy

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Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Author(s) -

Matthew D. Lynes,

Farnaz Shamsi,

Elahu G. Sustarsic,

Luiz O. Leiria,

ChihHao Wang,

ShengChiang Su,

Tian Lian Huang,

Fei Gao,

Niven R. Narain,

Emily Y. Chen,

Aaron M. Cypess,

Tim J. Schulz,

Zachary GerhartHines,

Michael A. Kiebish,

YuHua Tseng

Publication year - 2018

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2018.06.073

Subject(s) - cardiolipin , adipose tissue , lipid metabolism , metabolism , dynamics (music) , thermogenesis , microbiology and biotechnology , biology , chemistry , biochemistry , phospholipid , membrane , physics , acoustics

Thermogenic fat expends energy during cold for temperature homeostasis, and its activity regulates nutrient metabolism and insulin sensitivity. We measured cold-activated lipid landscapes in circulation and in adipose tissue by MS/MS ALL shotgun lipidomics. We created an interactive online viewer to visualize the changes of specific lipid species in response to cold. In adipose tissue, among the approximately 1,600 lipid species profiled, we identified the biosynthetic pathway of the mitochondrial phospholipid cardiolipin as coordinately activated in brown and beige fat by cold in wild-type and transgenic mice with enhanced browning of white fat. Together, these data provide a comprehensive lipid bio-signature of thermogenic fat activation in circulation and tissue and suggest pathways regulated by cold exposure.

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