Open AccessA Mouse Ependymoma Model Provides Molecular Insights into Tumor Formation
Author(s) -
Kristian W. Pajtler,
Stefan M. Pfister
Publication year - 2018
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2018.06.062
Subject(s) - ependymoma , computational biology , biology , neuroscience , microbiology and biotechnology , medicine , pathology
Ozawa et al. present a murine tumor model resembling the most frequent molecular group of human supratentorial ependymoma, ST-EPN-RELA. Their model shows RELA-fusion-based de novo ependymoma tumorigenesis in the forebrain derived from neural stem cells.
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