RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment | Zendy

Eva Benito | Zendy; Cemil Kerimoglu | Zendy; Binu Ramachandran | Zendy; Tonatiuh PenaCenteno | Zendy; Gaurav Jain | Zendy; Roman M. Stilling | Zendy; Rezaul Islam | Zendy; Vincenzo Capece | Zendy; Qihui Zhou | Zendy; Dieter Edbauer | Zendy; Camin Dean | Zendy; André Fischer | Zendy

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RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment

Author(s) -

Eva Benito,

Cemil Kerimoglu,

Binu Ramachandran,

Tonatiuh PenaCenteno,

Gaurav Jain,

Roman M. Stilling,

Rezaul Islam,

Vincenzo Capece,

Qihui Zhou,

Dieter Edbauer,

Camin Dean,

André Fischer

Publication year - 2018

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2018.03.059

Subject(s) - inheritance (genetic algorithm) , plasticity , synaptic plasticity , rna , biology , environmental enrichment , phenotypic plasticity , developmental plasticity , genetics , evolutionary biology , neuroscience , gene , physics , receptor , thermodynamics

Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.

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