A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present | Zendy

Jianpeng Sheng | Zendy; Qi Chen | Zendy; Irene Soncin | Zendy; See Liang Ng | Zendy; Klaus Karjalainen | Zendy; Christiane Ruedl | Zendy

Open Access

A Discrete Subset of Monocyte-Derived Cells among Typical Conventional Type 2 Dendritic Cells Can Efficiently Cross-Present

Author(s) -

Jianpeng Sheng,

Qi Chen,

Irene Soncin,

See Liang Ng,

Klaus Karjalainen,

Christiane Ruedl

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.10.024

Subject(s) - cross presentation , phenotype , monocyte , microbiology and biotechnology , biology , dendritic cell , antigen presentation , population , functional specialization , immunology , antigen , t cell , immune system , neuroscience , genetics , gene , medicine , environmental health

Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.

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