Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination | Zendy

Alerie Guzman de la Fuente | Zendy; Simona Lange | Zendy; Maria Elena Silva | Zendy; Ginez A. González | Zendy; Herbert Tempfer | Zendy; Peter van Wijngaarden | Zendy; Chao Zhao | Zendy; Ludovica Di Canio | Zendy; Andrea Trost | Zendy; Lara Bieler | Zendy; Pia Zaunmair | Zendy; Peter Rotheneichner | Zendy; Anna O’Sullivan | Zendy; Sébastien CouillardDesprés | Zendy; Oihana Errea | Zendy; Maarja Andaloussi Mäe | Zendy; Johanna Andræ | Zendy; Liqun He | Zendy; Annika Keller | Zendy; Luis Federico Bátiz | Zendy; Christer Betsholtz | Zendy; Ludwig Aigner | Zendy; Robin J.M. Franklin | Zendy; Francisco J. Rivera | Zendy

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Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

Author(s) -

Alerie Guzman de la Fuente,

Simona Lange,

Maria Elena Silva,

Ginez A. González,

Herbert Tempfer,

Peter van Wijngaarden,

Chao Zhao,

Ludovica Di Canio,

Andrea Trost,

Lara Bieler,

Pia Zaunmair,

Peter Rotheneichner,

Anna O’Sullivan,

Sébastien CouillardDesprés,

Oihana Errea,

Maarja Andaloussi Mäe,

Johanna Andræ,

Liqun He,

Annika Keller,

Luis Federico Bátiz,

Christer Betsholtz,

Ludwig Aigner,

Robin J.M. Franklin,

Francisco J. Rivera

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.08.007

Subject(s) - remyelination , progenitor cell , oligodendrocyte , regeneration (biology) , biology , microbiology and biotechnology , progenitor , myelin , neuroscience , galactocerebroside , stem cell , cellular differentiation , immunology , central nervous system , biochemistry , gene

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfb ret/ret mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration.

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