Open AccessmTORC1 Controls Synthesis of Its Activator GTP
Author(s) -
Don Benjamin,
Michael N. Hall
Publication year - 2017
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2017.06.032
Subject(s) - mtorc1 , activator (genetics) , gtp' , microbiology and biotechnology , computational biology , chemistry , biology , biochemistry , signal transduction , gene , pi3k/akt/mtor pathway , enzyme
In this issue of Cell Reports, Emmanuel et al. (2017) report that mTORC1 activity is regulated by purine availability. This increases the number of mTORC1 regulators to include metabolites whose synthesis mTORC1 controls.
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