The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands | Zendy

Hugo G. Hilton | Zendy; Curtis McMurtrey | Zendy; Alex S. Han | Zendy; Zakia Djaoud | Zendy; Lisbeth A. Guethlein | Zendy; Jeroen H. Blokhuis | Zendy; Jason L. Pugh | Zendy; Ana Goyos | Zendy; Amir Horowitz | Zendy; Rico Buchli | Zendy; Ken W. Jackson | Zendy; Wilfred Bardet | Zendy; David Bushnell | Zendy; Phillip J. Robinson | Zendy; Juan L. Mendoza | Zendy; Michael E. Birnbaum | Zendy; Morten Nielsen | Zendy; K. Christopher García | Zendy; William H. Hildebrand | Zendy; Peter Parham | Zendy

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The Intergenic Recombinant HLA-B∗46:01 Has a Distinctive Peptidome that Includes KIR2DL3 Ligands

Author(s) -

Hugo G. Hilton,

Curtis McMurtrey,

Alex S. Han,

Zakia Djaoud,

Lisbeth A. Guethlein,

Jeroen H. Blokhuis,

Jason L. Pugh,

Ana Goyos,

Amir Horowitz,

Rico Buchli,

Ken W. Jackson,

Wilfred Bardet,

David Bushnell,

Phillip J. Robinson,

Juan L. Mendoza,

Michael E. Birnbaum,

Morten Nielsen,

K. Christopher García,

William H. Hildebrand,

Peter Parham

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.04.059

Subject(s) - recombinant dna , intergenic region , biology , genetics , computational biology , human leukocyte antigen , microbiology and biotechnology , gene , genome , antigen

HLA-B ∗ 46:01 was formed by an intergenic mini-conversion, between HLA-B ∗ 15:01 and HLA-C ∗ 01:02, in Southeast Asia during the last 50,000 years, and it has since become the most common HLA-B allele in the region. A functional effect of the mini-conversion was introduction of the C1 epitope into HLA-B ∗ 46:01, making it an exceptional HLA-B allotype that is recognized by the C1-specific natural killer (NK) cell receptor KIR2DL3. High-resolution mass spectrometry showed that HLA-B ∗ 46:01 has a low-diversity peptidome that is distinct from those of its parents. A minority (21%) of HLA-B ∗ 46:01 peptides, with common C-terminal characteristics, form ligands for KIR2DL3. The HLA-B ∗ 46:01 peptidome is predicted to be enriched for peptide antigens derived from Mycobacterium leprae. Overall, the results indicate that the distinctive peptidome and functions of HLA-B ∗ 46:01 provide carriers with resistance to leprosy, which drove its rapid rise in frequency in Southeast Asia.

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