T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP | Zendy

Lisa Perruzza | Zendy; Giorgio Gargari | Zendy; Michele Proietti | Zendy; Bruno Fosso | Zendy; Anna Maria D’Erchia | Zendy; Caterina E. Faliti | Zendy; Tanja Rezzonico-Jost | Zendy; Daniela Scribano | Zendy; Laura Mauri | Zendy; Diego Colombo | Zendy; Giovanni Pellegrini | Zendy; Annalisa Moregola | Zendy; Catherine Mooser | Zendy; Graziano Pesole | Zendy; Mauro Nicoletti | Zendy; Giuseppe Danilo Norata | Zendy; Markus B. Geuking | Zendy; Kathy D. McCoy | Zendy; Simone Guglielmetti | Zendy; Fabio Grassi | Zendy

Open Access

T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP

Author(s) -

Lisa Perruzza,

Giorgio Gargari,

Michele Proietti,

Bruno Fosso,

Anna Maria D’Erchia,

Caterina E. Faliti,

Tanja Rezzonico-Jost,

Daniela Scribano,

Laura Mauri,

Diego Colombo,

Giovanni Pellegrini,

Annalisa Moregola,

Catherine Mooser,

Graziano Pesole,

Mauro Nicoletti,

Giuseppe Danilo Norata,

Markus B. Geuking,

Kathy D. McCoy,

Simone Guglielmetti,

Fabio Grassi

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.02.061

Subject(s) - extracellular , biology , microbiology and biotechnology , secretion , homeostasis , gut flora , paneth cell , cell , small intestine , immunology , biochemistry

The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.

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