Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer | Zendy

Mauricio Medrano | Zendy; Laudine Communal | Zendy; Kevin R. Brown | Zendy; Marcin Iwanicki | Zendy; Josée Normand | Zendy; Joshua Paterson | Zendy; Fabrice Sircoulomb | Zendy; Paul M. Krzyzanowski | Zendy; Marián Novak | Zendy; Sasha A. Doodnauth | Zendy; Fernando Suárez | Zendy; Jane Cullis | Zendy; Rima Alawar | Zendy; Benjamin G. Neel | Zendy; John D. McPherson | Zendy; Ronny Drapkin | Zendy; Laurie Ailles | Zendy; AnneMarie MesMasson | Zendy; Robert Rottapel | Zendy

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Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer

Author(s) -

Mauricio Medrano,

Laudine Communal,

Kevin R. Brown,

Marcin Iwanicki,

Josée Normand,

Joshua Paterson,

Fabrice Sircoulomb,

Paul M. Krzyzanowski,

Marián Novak,

Sasha A. Doodnauth,

Fernando Suárez,

Jane Cullis,

Rima Alawar,

Benjamin G. Neel,

John D. McPherson,

Ronny Drapkin,

Laurie Ailles,

AnneMarie MesMasson,

Robert Rottapel

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.02.028

Subject(s) - ovarian cancer , tetraspanin , biology , serous fluid , cancer research , serous ovarian cancer , rna interference , gene , cancer , cell , computational biology , genetics , rna , biochemistry

The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression analysis of cell-surface markers in a panel of HGSC cell lines to identify genes that are critical to their survival. We report that the tetraspanin CD151 contributes to survival of a subset of HGSC cell lines associated with a ZEB transcriptional program and supports the growth of HGSC tumors. Moreover, we show that high CD151 expression is prognostic of poor clinical outcome. This study reveals cell-surface vulnerabilities associated with HGSC, provides a framework for identifying therapeutic targets, and reports a role for CD151 in HGSC.

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