Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans | Zendy

Leonore Wigger | Zendy; Céline CrucianiGuglielmacci | Zendy; Anthony Nicolas | Zendy; Jessica Denom | Zendy; Neïké Fernandez | Zendy; Frédéric Fumeron | Zendy; Pedro MarquesVidal | Zendy; Alain Ktorza | Zendy; Werner Kramer | Zendy; Anke M. Schulte | Zendy; Hervé Le Stunff | Zendy; Robin Liechti | Zendy; Ioannis Xénarios | Zendy; Péter Vollenweider | Zendy; Gérard Waeber | Zendy; Ingo Uphues | Zendy; Ronan Roussel | Zendy; Chr̀istophe Magnan | Zendy; Mark Ibberson | Zendy; Bernard Thorens | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

Author(s) -

Leonore Wigger,

Céline CrucianiGuglielmacci,

Anthony Nicolas,

Jessica Denom,

Neïké Fernandez,

Frédéric Fumeron,

Pedro MarquesVidal,

Alain Ktorza,

Werner Kramer,

Anke M. Schulte,

Hervé Le Stunff,

Robin Liechti,

Ioannis Xénarios,

Péter Vollenweider,

Gérard Waeber,

Ingo Uphues,

Ronan Roussel,

Chr̀istophe Magnan,

Mark Ibberson,

Bernard Thorens

Publication year - 2017

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2017.02.019

Subject(s) - sphingolipid , diabetes mellitus , biomarker , biology , medicine , type 2 diabetes , endocrinology , population , metabolite , lipidomics , glucose homeostasis , pathogenesis , homeostasis , insulin resistance , bioinformatics , biochemistry , environmental health

Plasma metabolite concentrations reflect the activity of tissue metabolic pathways and their quantitative determination may be informative about pathogenic conditions. We searched for plasma lipid species whose concentrations correlate with various parameters of glucose homeostasis and susceptibility to type 2 diabetes (T2D). Shotgun lipidomic analysis of the plasma of mice from different genetic backgrounds, which develop a pre-diabetic state at different rates when metabolically stressed, led to the identification of a group of sphingolipids correlated with glucose tolerance and insulin secretion. Quantitative analysis of these and closely related lipids in the plasma of individuals from two population-based prospective cohorts revealed that specific long-chain fatty-acid-containing dihydroceramides were significantly elevated in the plasma of individuals who will progress to diabetes up to 9 years before disease onset. These lipids may serve as early biomarkers of, and help identify, metabolic deregulation in the pathogenesis of T2D.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research