Open AccessTRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells
Author(s) -
Per Ludvik Brattås,
Marie E. Jönsson,
Liana Fasching,
Jenny Nelander Wahlestedt,
Mansoureh Shahsavani,
Ronny Falk,
Anna Falk,
Patric Jern,
Malin Parmar,
Johan Jakobsson
Publication year - 2017
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2016.12.010
Subject(s) - endogenous retrovirus , progenitor cell , gene , endogeny , neural stem cell , progenitor , biology , genetics , gene regulatory network , microbiology and biotechnology , computational biology , neuroscience , stem cell , gene expression , genome , endocrinology
Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.
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