Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits | Zendy

Raúl AguirreGamboa | Zendy; Irma Joosten | Zendy; Paulo C. M. Urbano | Zendy; Renate G. van der Molen | Zendy; Esther van Rijssen | Zendy; Bram van Cranenbroek | Zendy; Marije Oosting | Zendy; Sanne P. Smeekens | Zendy; Martin Jaeger | Zendy; Maria M. Zorro | Zendy; Sebo Withoff | Zendy; Antonius E. van Herwaarden | Zendy; Fred C.G.J. Sweep | Zendy; Romana T. Netea | Zendy; Morris A. Swertz | Zendy; Lude Franke | Zendy; Ramnik J. Xavier | Zendy; Leo A. B. Joosten | Zendy; Mihai G. Netea | Zendy; Cisca Wijmenga | Zendy; Vinod Kumar | Zendy; Yang Li | Zendy; Hans J. P. M. Koenen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

Author(s) -

Raúl AguirreGamboa,

Irma Joosten,

Paulo C. M. Urbano,

Renate G. van der Molen,

Esther van Rijssen,

Bram van Cranenbroek,

Marije Oosting,

Sanne P. Smeekens,

Martin Jaeger,

Maria M. Zorro,

Sebo Withoff,

Antonius E. van Herwaarden,

Fred C.G.J. Sweep,

Romana T. Netea,

Morris A. Swertz,

Lude Franke,

Ramnik J. Xavier,

Leo A. B. Joosten,

Mihai G. Netea,

Cisca Wijmenga,

Vinod Kumar,

Yang Li,

Hans J. P. M. Koenen

Publication year - 2016

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2016.10.053

Subject(s) - biology , immune system , genome wide association study , quantitative trait locus , heritability , genetics , genetic association , single nucleotide polymorphism , genetic variation , genomics , immunology , phenotype , computational biology , genome , genotype , gene

Effective immunity requires a complex network of cellular and humoral components that interact with each other and are influenced by different environmental and host factors. We used a systems biology approach to comprehensively assess the impact of environmental and genetic factors on immune cell populations in peripheral blood, including associations with immunoglobulin concentrations, from ∼500 healthy volunteers from the Human Functional Genomics Project. Genetic heritability estimation showed that variations in T cell numbers are more strongly driven by genetic factors, while B cell counts are more environmentally influenced. Quantitative trait loci (QTL) mapping identified eight independent genomic loci associated with leukocyte count variation, including four associations with T and B cell subtypes. The QTLs identified were enriched among genome-wide association study (GWAS) SNPs reported to increase susceptibility to immune-mediated diseases. Our systems approach provides insights into cellular and humoral immune trait variability in humans.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research