Open AccessA Metabolic Roadblock in Inflammatory Macrophages
Author(s) -
Luke O'neill
Publication year - 2016
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2016.09.085
Subject(s) - inflammation , macrophage , biology , immunology , chemistry , microbiology and biotechnology , biochemistry , in vitro
In this issue of Cell Reports, Van den Bossche et al. (2016) reveal that, once the M1 macrophage forms, the accompanying metabolic alterations in the mitochondria are irreversible, preventing differentiation into the more homeostatic M2 macrophage.
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