Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer | Zendy

Nadine S. Jahchan | Zendy; Jing Lim | Zendy; Becky M. Bola | Zendy; Karen Morris | Zendy; Garrett Seitz | Zendy; Kim Q.T. Tran | Zendy; Lei Xu | Zendy; Francesca Trapani | Zendy; Christopher J. Morrow | Zendy; Sandra Cristea | Zendy; Garry L. Coles | Zendy; Dian Yang | Zendy; Dedeepya Vaka | Zendy; Michael S. Kareta | Zendy; Julie George | Zendy; Paweł K. Mazur | Zendy; Thuyen Nguyen | Zendy; Wade Anderson | Zendy; Scott J. Dylla | Zendy; Fiona Blackhall | Zendy; Martin Peifer | Zendy; Caroline Dive | Zendy; Julien Sage | Zendy

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Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

Author(s) -

Nadine S. Jahchan,

Jing Lim,

Becky M. Bola,

Karen Morris,

Garrett Seitz,

Kim Q.T. Tran,

Lei Xu,

Francesca Trapani,

Christopher J. Morrow,

Sandra Cristea,

Garry L. Coles,

Dian Yang,

Dedeepya Vaka,

Michael S. Kareta,

Julie George,

Paweł K. Mazur,

Thuyen Nguyen,

Wade Anderson,

Scott J. Dylla,

Fiona Blackhall,

Martin Peifer,

Caroline Dive,

Julien Sage

Publication year - 2016

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2016.06.021

Subject(s) - cancer research , cd24 , population , lung cancer , biology , neuroendocrine tumors , chemotherapy , cancer , cell , small cell lung carcinoma , cell growth , cancer cell , pathology , medicine , cd44 , genetics , small cell carcinoma , endocrinology , environmental health

Small cell lung cancer (SCLC) is a neuroendocrine lung cancer characterized by fast growth, early dissemination, and rapid resistance to chemotherapy. We identified a population of long-term tumor-propagating cells (TPCs) in a mouse model of SCLC. This population, marked by high levels of EpCAM and CD24, is also prevalent in human primary SCLC tumors. Murine SCLC TPCs are numerous and highly proliferative but not intrinsically chemoresistant, indicating that not all clinical features of SCLC are linked to TPCs. SCLC TPCs possess a distinct transcriptional profile compared to non-TPCs, including elevated MYC activity. Genetic and pharmacological inhibition of MYC in SCLC cells to non-TPC levels inhibits long-term propagation but not short-term growth. These studies identify a highly tumorigenic population of SCLC cells in mouse models, cell lines, and patient tumors and a means to target them in this most fatal form of lung cancer.

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