Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans | Zendy

Lisa L. Liu | Zendy; Johannes Landskron | Zendy; Eivind Heggernes Ask | Zendy; Monika Enqvist | Zendy; Ebba Sohlberg | Zendy; James A. Traherne | Zendy; Quirin Hammer | Zendy; Jodie P. Goodridge | Zendy; Stella Larsson | Zendy; Jyothi Jayaraman | Zendy; Vincent Yi Sheng Oei | Zendy; Marie Schaffer | Zendy; Kjetil Taskén | Zendy; HansGustaf Ljunggren | Zendy; Chiara Romagnani | Zendy; John Trowsdale | Zendy; KarlJohan Malmberg | Zendy; Vivien Béziat | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans

Author(s) -

Lisa L. Liu,

Johannes Landskron,

Eivind Heggernes Ask,

Monika Enqvist,

Ebba Sohlberg,

James A. Traherne,

Quirin Hammer,

Jodie P. Goodridge,

Stella Larsson,

Jyothi Jayaraman,

Vincent Yi Sheng Oei,

Marie Schaffer,

Kjetil Taskén,

HansGustaf Ljunggren,

Chiara Romagnani,

John Trowsdale,

KarlJohan Malmberg,

Vivien Béziat

Publication year - 2016

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2016.04.005

Subject(s) - stimulation , microbiology and biotechnology , cell , biology , neuroscience , natural killer cell , immunology , genetics , cytotoxic t cell , in vitro

Infection by human cytomegalovirus (HCMV) leads to NKG2C-driven expansion of adaptive natural killer (NK) cells, contributing to host defense. However, approximately 4% of all humans carry a homozygous deletion of the gene that encodes NKG2C (NKG2C(-/-)). Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-γ promoter. We found that both NKG2C(-) and NKG2C(+) adaptive NK cells expressed high levels of CD2, which synergistically enhanced ERK and S6RP phosphorylation following CD16 ligation. Notably, CD2 co-stimulation was critical for the ability of adaptive NK cells to respond to antibody-coated target cells. These results reveal an unexpected redundancy in the human NK cell response to HCMV and suggest that CD2 provides "signal 2" in antibody-driven adaptive NK cell responses.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research