Open AccessCommon-Lymphoid-Progenitor-Independent Pathways of Innate and T Lymphocyte Development
Author(s) -
Maryam Ghaedi,
Catherine A. Steer,
Itziar Martínez-González,
Timotheus Y.F. Halim,
Ninan Abraham,
Fumio Takei
Publication year - 2016
Publication title -
cell reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.264
H-Index - 154
eISSN - 2639-1856
pISSN - 2211-1247
DOI - 10.1016/j.celrep.2016.03.039
Subject(s) - innate lymphoid cell , interleukin 7 receptor , biology , progenitor cell , immunology , lymphopoiesis , progenitor , transplantation , lymphocyte , immune system , innate immune system , microbiology and biotechnology , stem cell , t cell , medicine , il 2 receptor
All lymphocytes are thought to develop from common lymphoid progenitors (CLPs). However, lymphoid-primed multipotent progenitors (LMPPs) are more efficient than CLPs in differentiating into T cells and group 2 innate lymphoid cells (ILC2s). Here, we have divided LMPPs into CD127(-) (LMPP-s) and CD127(+) (LMPP+s) subsets and compared them with Ly6D(-) and Ly6D(+) CLPs. Adult LMPP+s differentiated into T cells and ILCs more rapidly and efficiently than other progenitors in transplantation assays. The development of T cells and ILC2s is highly active in the neonatal period. Neonatal CLPs are rare and, unlike prominent neonatal LMPP+s, do not efficiently differentiate into T cells and ILC2s. ILC2s generated in the neonatal period are long lived and persist in adult tissues. These results suggest that some ILCs and T cells may develop from LMPP+s via CLP-independent pathways.
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