Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine | Zendy

Christelle Glangetas | Zendy; Giulia R. Fois | Zendy; Marion Jalabert | Zendy; Salvatore Lecca | Zendy; Kristina Valentinova | Zendy; Frank J. Meye | Zendy; Marco Diana | Zendy; Philippe Fauré | Zendy; Manuel Mameli | Zendy; Stéphanie Caillé | Zendy; François Georges | Zendy

Open Access

Ventral Subiculum Stimulation Promotes Persistent Hyperactivity of Dopamine Neurons and Facilitates Behavioral Effects of Cocaine

Author(s) -

Christelle Glangetas,

Giulia R. Fois,

Marion Jalabert,

Salvatore Lecca,

Kristina Valentinova,

Frank J. Meye,

Marco Diana,

Philippe Fauré,

Manuel Mameli,

Stéphanie Caillé,

François Georges

Publication year - 2015

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2015.10.076

Subject(s) - subiculum , neuroscience , ventral tegmental area , dopamine , stria terminalis , biological neural network , premovement neuronal activity , long term potentiation , neurotransmission , stimulation , brain stimulation reward , nucleus accumbens , hippocampus , psychology , amygdala , medicine , dentate gyrus , receptor , dopaminergic

The ventral subiculum (vSUB) plays a key role in addiction, and identifying the neuronal circuits and synaptic mechanisms by which vSUB alters the excitability of dopamine neurons is a necessary step to understand the motor changes induced by cocaine. Here, we report that high-frequency stimulation of the vSUB (HFSvSUB) over-activates ventral tegmental area (VTA) dopamine neurons in vivo and triggers long-lasting modifications of synaptic transmission measured ex vivo. This potentiation is caused by NMDA-dependent plastic changes occurring in the bed nucleus of the stria terminalis (BNST). Finally, we report that the modification of the BNST-VTA neural circuits induced by HFSvSUB potentiates locomotor activity induced by a sub-threshold dose of cocaine. Our findings unravel a neuronal circuit encoding behavioral effects of cocaine in rats and highlight the importance of adaptive modifications in the BNST, a structure that influences motivated behavior as well as maladaptive behaviors associated with addiction.

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