Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development | Zendy

Ramanathan Narayanan | Zendy; Mehdi Pirouz | Zendy; Cemil Kerimoglu | Zendy; Linh Pham | Zendy; Robin J. Wagener | Zendy; Kamila A. Kiszka | Zendy; Joachim Rosenbusch | Zendy; Rho Hyun Seong | Zendy; Michael Kessel | Zendy; André Fischer | Zendy; Anastassia Stoykova | Zendy; Jochen F. Staiger | Zendy; Tran Tuoc | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Loss of BAF (mSWI/SNF) Complexes Causes Global Transcriptional and Chromatin State Changes in Forebrain Development

Author(s) -

Ramanathan Narayanan,

Mehdi Pirouz,

Cemil Kerimoglu,

Linh Pham,

Robin J. Wagener,

Kamila A. Kiszka,

Joachim Rosenbusch,

Rho Hyun Seong,

Michael Kessel,

André Fischer,

Anastassia Stoykova,

Jochen F. Staiger,

Tran Tuoc

Publication year - 2015

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2015.10.046

Subject(s) - chromatin , forebrain , microbiology and biotechnology , transcription factor , biology , chemistry , genetics , neuroscience , gene , central nervous system

BAF (Brg/Brm-associated factors) complexes play important roles in development and are linked to chromatin plasticity at selected genomic loci. Nevertheless, a full understanding of their role in development and chromatin remodeling has been hindered by the absence of mutants completely lacking BAF complexes. Here, we report that the loss of BAF155/BAF170 in double-conditional knockout (dcKO) mice eliminates all known BAF subunits, resulting in an overall reduction in active chromatin marks (H3K9Ac), a global increase in repressive marks (H3K27me2/3), and downregulation of gene expression. We demonstrate that BAF complexes interact with H3K27 demethylases (JMJD3 and UTX) and potentiate their activity. Importantly, BAF complexes are indispensable for forebrain development, including proliferation, differentiation, and cell survival of neural progenitor cells. Our findings reveal a molecular mechanism mediated by BAF complexes that controls the global transcriptional program and chromatin state in development.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research