Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain | Zendy

Marina E. Emborg | Zendy; Yan Liu | Zendy; Jiajie Xi | Zendy; Xiaoqing Zhang | Zendy; Yingnan Yin | Zendy; Jianfeng Lü | Zendy; Valerie Joers | Zendy; Christine R. Swanson | Zendy; James E. Holden | Zendy; SuChun Zhang | Zendy

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Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

Author(s) -

Marina E. Emborg,

Yan Liu,

Jiajie Xi,

Xiaoqing Zhang,

Yingnan Yin,

Jianfeng Lü,

Valerie Joers,

Christine R. Swanson,

James E. Holden,

SuChun Zhang

Publication year - 2013

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2013.02.016

Subject(s) - induced pluripotent stem cell , neural stem cell , neuroscience , progenitor cell , biology , mptp , primate , neurosphere , stem cell , embryonic stem cell , microbiology and biotechnology , adult stem cell , genetics , gene , dopaminergic , dopamine

The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.

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