Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration | Zendy

Lai Wei | Zendy; Baoying Liu | Zendy; Jingsheng Tuo | Zendy; Defen Shen | Zendy; Ping Chen | Zendy; Zhiyu Li | Zendy; Xunxian Liu | Zendy; Jia Ni | Zendy; Pradeep K. Dagur | Zendy; H. Nida Sen | Zendy; Shayma Jawad | Zendy; Diamond Ling | Zendy; Stanley Park | Zendy; Sagarika Chakrabarty | Zendy; Catherine Meyerle | Zendy; Elvira Agrón | Zendy; Frederick L. Ferris | Zendy; Emily Y. Chew | Zendy; J. Philip McCoy | Zendy; Emily Blum | Zendy; Peter J. Francis | Zendy; Michael L. Klein | Zendy; Robyn H. Guymer | Zendy; Paul N. Baird | Zendy; Chi-Chao Chan | Zendy; Robert B. Nussenblatt | Zendy

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Hypomethylation of the IL17RC Promoter Associates with Age-Related Macular Degeneration

Author(s) -

Lai Wei,

Baoying Liu,

Jingsheng Tuo,

Defen Shen,

Ping Chen,

Zhiyu Li,

Xunxian Liu,

Jia Ni,

Pradeep K. Dagur,

H. Nida Sen,

Shayma Jawad,

Diamond Ling,

Stanley Park,

Sagarika Chakrabarty,

Catherine Meyerle,

Elvira Agrón,

Frederick L. Ferris,

Emily Y. Chew,

J. Philip McCoy,

Emily Blum,

Peter J. Francis,

Michael L. Klein,

Robyn H. Guymer,

Paul N. Baird,

Chi-Chao Chan,

Robert B. Nussenblatt

Publication year - 2012

Publication title -

cell reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.264

H-Index - 154

eISSN - 2639-1856

pISSN - 2211-1247

DOI - 10.1016/j.celrep.2012.10.013

Subject(s) - macular degeneration , biomarker , dna methylation , biology , methylation , epigenetics , pathogenesis , promoter , microrna , disease , single nucleotide polymorphism , gene , genetics , population , gene expression , medicine , pathology , immunology , genotype , ophthalmology , environmental health

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population worldwide. Although recent studies have demonstrated strong genetic associations between AMD and SNPs in a number of genes, other modes of regulation are also likely to play a role in the etiology of this disease. We identified a significantly decreased level of methylation on the IL17RC promoter in AMD patients. Furthermore, we showed that hypomethylation of the IL17RC promoter in AMD patients led to an elevated expression of its protein and messenger RNA in peripheral blood as well as in the affected retina and choroid, suggesting that the DNA methylation pattern and expression of IL17RC may potentially serve as a biomarker for the diagnosis of AMD and likely plays a role in disease pathogenesis.

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