A proteogenomic portrait of lung squamous cell carcinoma | Zendy

Shankha Satpathy | Zendy; Karsten Krug | Zendy; Pierre M. Jean Beltran | Zendy; Sara R. Savage | Zendy; Francesca Petralia | Zendy; Chandan KumarSinha | Zendy; Yongchao Dou | Zendy; Boris Reva | Zendy; M. Harry Kane | Zendy; Shayan C. Avanessian | Zendy; Suhas Vasaikar | Zendy; Azra Krek | Zendy; Jonathan T. Lei | Zendy; Eric J. Jaehnig | Zendy; Tatiana Omelchenko | Zendy; Yifat Geffen | Zendy; Erik J. Bergstrom | Zendy; Vasileios Stathias | Zendy; Karen E. Christianson | Zendy; David I. Heiman | Zendy; Marcin Cieślik | Zendy; Song Cao | Zendy; Xiaoyu Song | Zendy; Jiayi Ji | Zendy; Wenke Liu | Zendy; Kai Li | Zendy; Bo Wen | Zendy; Yize Li | Zendy; Zeynep H. Gümüş | Zendy; Myvizhi Esai Selvan | Zendy; Rama Soundararajan | Zendy; Tanvi H. Visal | Zendy; Maria Gabriela Raso | Zendy; Edwin R. Parra | Zendy; Özgün Babur | Zendy; Pankaj Vats | Zendy; Shankara Anand | Zendy; Tobias Schraink | Zendy; MacIntosh Cornwell | Zendy; Fernanda Martins Rodrigues | Zendy; Houxiang Zhu | Zendy; Chia-Kuei Mo | Zendy; Yuping Zhang | Zendy; Felipe da Veiga Leprevost | Zendy; Chen Huang | Zendy; Arul M. Chinnaiyan | Zendy; Matthew A. Wyczalkowski | Zendy; Gilbert S. Omenn | Zendy; Chelsea J. Newton | Zendy; Stephan C. Schürer | Zendy; Kelly V. Ruggles | Zendy; David Fenyö | Zendy; Scott D. Jewell | Zendy; Mathangi Thiagarajan | Zendy; Mehdi Mesri | Zendy; Henry Rodriguez | Zendy; Sendurai A. Mani | Zendy; Namrata D. Udeshi | Zendy; Gad Getz | Zendy; James Suh | Zendy; Qing Kay Li | Zendy; Galen Hostetter | Zendy; Paul K. Paik | Zendy; Saravana M. Dhanasekaran | Zendy; Ramaswamy Govindan | Zendy; Li Ding | Zendy; Ana I. Robles | Zendy; Karl R. Clauser | Zendy; Alexey I. Nesvizhskii | Zendy; Pei Wang | Zendy; Steven A. Carr | Zendy; Bing Zhang | Zendy; D.R. Mani | Zendy; Michael A. Gillette | Zendy; Alexander L. Green | Zendy; Alfredo Molinolo | Zendy; Alicia Francis | Zendy; Amanda G. Paulovich | Zendy; Andrii Karnuta | Zendy; Antonio Colaprico | Zendy; Barbara Hindenach | Zendy; Barbara L. Pruetz | Zendy; Bartosz Kubisa | Zendy; Brian J. Druker | Zendy; Carissa A. Huynh | Zendy; Charles A. Goldthwaite | Zendy; Chet Birger | Zendy; Christopher R. Kinsinger | Zendy; Corbin D. Jones | Zendy; Dan Rohrer | Zendy; Dana R. Valley | Zendy; Daniel W. Chan | Zendy; David Chesla | Zendy; Donna E. Hansel | Zendy; Elena V. Ponomareva | Zendy; Elizabeth R. Duffy | Zendy; Eric Burks | Zendy; Eric E. Schadt | Zendy; Eugene S. Fedorov | Zendy; Eunkyung An | Zendy; Fei Ding | Zendy; George D. Wilson | Zendy; Harsh Vardhan Batra | Zendy; Hui Zhang | Zendy; Jennifer E. Maas | Zendy; Jennifer Eschbacher | Zendy; Karen A. Ketchum | Zendy; Karin Rodland | Zendy; Katherine A. Hoadley | Zendy; Kei Suzuki | Zendy; Ki Sung Um | Zendy; Liqun Qi | Zendy; Lori Lynn Bernard | Zendy; Maciej Wiznerowicz | Zendy; Małgorzata Wojtyś | Zendy; Marcin J. Domagalski | Zendy; Matthew J. Ellis | Zendy; Maureen A. Dyer | Zendy; Melissa Borucki | Zendy; Meenakshi Anurag | Zendy; Michael J. Birrer | Zendy; Midie Xu | Zendy; Mikhail Krotevich | Zendy; Nancy Roche | Zendy; Nathan Edwards | Zendy; Negin Vatanian | Zendy; Neil R. Mucci | Zendy; Nicollette Maunganidze | Zendy; N Gabrovski | Zendy; Olga Potapova | Zendy; Oluwole Fadare | Zendy; Pamela Grady | Zendy; Peter B. McGarvey | Zendy; Pushpa Hariharan | Zendy; Ratna R. Thangudu | Zendy; Rebecca Montgomery | Zendy; Renganayaki Pandurengan | Zendy; Richard Smith | Zendy; Robert Welsh | Zendy; Sailaja Mareedu | Zendy; Samuel Payne | Zendy; Sandra Cottingham | Zendy; Shilpi Singh | Zendy; Shirley Tsang | Zendy; Shuang Cai | Zendy; Stacey Gabriel | Zendy; Tao Liu | Zendy; Tara Hiltke | Zendy; Tanmayi D. Vashist | Zendy; Thomas Bauer | Zendy; Volodymyr Sovenko | Zendy; Warren G. Tourtellotte | Zendy; Weiping Ma | Zendy; William Bocik | Zendy; Wohaib Hasan | Zendy; Xiaojun Jing | Zendy; Ximing Tang | Zendy; Yuxing Liao | Zendy; Yvonne | Zendy; Shutack | Zendy; Zhen Zhang | Zendy; Ziad Hanhan | Zendy

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A proteogenomic portrait of lung squamous cell carcinoma

Author(s) -

Shankha Satpathy,

Karsten Krug,

Pierre M. Jean Beltran,

Sara R. Savage,

Francesca Petralia,

Chandan KumarSinha,

Yongchao Dou,

Boris Reva,

M. Harry Kane,

Shayan C. Avanessian,

Suhas Vasaikar,

Azra Krek,

Jonathan T. Lei,

Eric J. Jaehnig,

Tatiana Omelchenko,

Yifat Geffen,

Erik J. Bergstrom,

Vasileios Stathias,

Karen E. Christianson,

David I. Heiman,

Marcin Cieślik,

Song Cao,

Xiaoyu Song,

Jiayi Ji,

Wenke Liu,

Kai Li,

Bo Wen,

Yize Li,

Zeynep H. Gümüş,

Myvizhi Esai Selvan,

Rama Soundararajan,

Tanvi H. Visal,

Maria Gabriela Raso,

Edwin R. Parra,

Özgün Babur,

Pankaj Vats,

Shankara Anand,

Tobias Schraink,

MacIntosh Cornwell,

Fernanda Martins Rodrigues,

Houxiang Zhu,

Chia-Kuei Mo,

Yuping Zhang,

Felipe da Veiga Leprevost,

Chen Huang,

Arul M. Chinnaiyan,

Matthew A. Wyczalkowski,

Gilbert S. Omenn,

Chelsea J. Newton,

Stephan C. Schürer,

Kelly V. Ruggles,

David Fenyö,

Scott D. Jewell,

Mathangi Thiagarajan,

Mehdi Mesri,

Henry Rodriguez,

Sendurai A. Mani,

Namrata D. Udeshi,

Gad Getz,

James Suh,

Qing Kay Li,

Galen Hostetter,

Paul K. Paik,

Saravana M. Dhanasekaran,

Ramaswamy Govindan,

Li Ding,

Ana I. Robles,

Karl R. Clauser,

Alexey I. Nesvizhskii,

Pei Wang,

Steven A. Carr,

Bing Zhang,

D.R. Mani,

Michael A. Gillette,

Alexander L. Green,

Alfredo Molinolo,

Alicia Francis,

Amanda G. Paulovich,

Andrii Karnuta,

Antonio Colaprico,

Barbara Hindenach,

Barbara L. Pruetz,

Bartosz Kubisa,

Brian J. Druker,

Carissa A. Huynh,

Charles A. Goldthwaite,

Chet Birger,

Christopher R. Kinsinger,

Corbin D. Jones,

Dan Rohrer,

Dana R. Valley,

Daniel W. Chan,

David Chesla,

Donna E. Hansel,

Elena V. Ponomareva,

Elizabeth R. Duffy,

Eric Burks,

Eric E. Schadt,

Eugene S. Fedorov,

Eunkyung An,

Fei Ding,

George D. Wilson,

Harsh Vardhan Batra,

Hui Zhang,

Jennifer E. Maas,

Jennifer Eschbacher,

Karen A. Ketchum,

Karin Rodland,

Katherine A. Hoadley,

Kei Suzuki,

Ki Sung Um,

Liqun Qi,

Lori Lynn Bernard,

Maciej Wiznerowicz,

Małgorzata Wojtyś,

Marcin J. Domagalski,

Matthew J. Ellis,

Maureen A. Dyer,

Melissa Borucki,

Meenakshi Anurag,

Michael J. Birrer,

Midie Xu,

Mikhail Krotevich,

Nancy Roche,

Nathan Edwards,

Negin Vatanian,

Neil R. Mucci,

Nicollette Maunganidze,

N Gabrovski,

Olga Potapova,

Oluwole Fadare,

Pamela Grady,

Peter B. McGarvey,

Pushpa Hariharan,

Ratna R. Thangudu,

Rebecca Montgomery,

Renganayaki Pandurengan,

Richard Smith,

Robert Welsh,

Sailaja Mareedu,

Samuel Payne,

Sandra Cottingham,

Shilpi Singh,

Shirley Tsang,

Shuang Cai,

Stacey Gabriel,

Tao Liu,

Tara Hiltke,

Tanmayi D. Vashist,

Thomas Bauer,

Volodymyr Sovenko,

Warren G. Tourtellotte,

Weiping Ma,

William Bocik,

Wohaib Hasan,

Xiaojun Jing,

Ximing Tang,

Yuxing Liao,

Yvonne,

Shutack,

Zhen Zhang,

Ziad Hanhan

Publication year - 2021

Publication title -

cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 26.304

H-Index - 776

eISSN - 1097-4172

pISSN - 0092-8674

DOI - 10.1016/j.cell.2021.07.016

Subject(s) - proteogenomics , biology , cancer research , cyclin dependent kinase 1 , cdkn2a , sox2 , cell cycle , computational biology , ezh2 , bioinformatics , cancer , chromatin , genomics , genetics , gene , transcription factor , genome

Lung squamous cell carcinoma (LSCC) remains a leading cause of cancer death with few therapeutic options. We characterized the proteogenomic landscape of LSCC, providing a deeper exposition of LSCC biology with potential therapeutic implications. We identify NSD3 as an alternative driver in FGFR1-amplified tumors and low-p63 tumors overexpressing the therapeutic target survivin. SOX2 is considered undruggable, but our analyses provide rationale for exploring chromatin modifiers such as LSD1 and EZH2 to target SOX2-overexpressing tumors. Our data support complex regulation of metabolic pathways by crosstalk between post-translational modifications including ubiquitylation. Numerous immune-related proteogenomic observations suggest directions for further investigation. Proteogenomic dissection of CDKN2A mutations argue for more nuanced assessment of RB1 protein expression and phosphorylation before declaring CDK4/6 inhibition unsuccessful. Finally, triangulation between LSCC, LUAD, and HNSCC identified both unique and common therapeutic vulnerabilities. These observations and proteogenomics data resources may guide research into the biology and treatment of LSCC.

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